Mntambo often uses her own body as her subject or as inspiration to bring issues of identity and conflict to the forefront, and she frequently addresses the dynamic tension that exists within the self, the push-pull between libido and mortido, life instinct and death drive. Concepts of powerlessness versus empowerment, the public versus the private selves, or the presentation of unexpected role reversals have arisen in some of her latest bodies of work. She is also very interested in bull mythology throughout various cultures. Her themes and practices range from the rehearsal and photography of the steps of a bullfighter in the abandoned Praça de Touros in Maputo to re-imagining the Greek myth The Rape of Europa. Mntambo has developed a unique aesthetic through the use of cowhide. The artist breaks down, molds and casts the cowhide to create masks, body armor, and adornments allowing for her to organically transform into her characters.
Mntambo currently has work included in the exhibition space: Currencies in Contemporary African Art at Museum Africa in Newtown, Johannesburg (May 11 – July 11). This Pan African exhibition is a 2010 FIFA World Cup Host City Johannesburg Event. She has had two solo exhibitions at Michael Stevenson, a contemporary gallery located in Woodstock, Capetown. The artist has shown internationally in group exhibitions in Denmark, Germany, and the UK, among others. She has also presented work in two exhibitions in the United States: Undercover: Performing and Transforming Black Female Identities, Spelman College Museum of Fine Art, Atlanta; and Black Womanhood: Images, Icons, and Ideologies of the African Body, Hood Museum of Art, Dartmouth College, Hanover, New Hampshire. Her work is currently included in the following venues throughout the summer of 2010: The 17th Biennale of Sydney (May 12 – August 12); Dak'Art, the 9th Dakar Biennale (May 7 – June 7); and Ampersand at Daimler Contemporary, Berlin (June 10 – October 10).